TCF7L2 [The Human Chemical-Genetic Interaction Map Project]

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======= TCF7L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCF7L2
  * **<color #00a2e8>Official Name</color>**: transcription factor 7 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6934|6934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQB0|Q9NQB0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCF7L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCF7L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602228|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CTNNB1 binding|
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|
|regulation of heparan sulfate proteoglycan biosynthetic process|
|beta-catenin-TCF7L2 complex|
|positive regulation of proteoglycan biosynthetic process|
|positive regulation of heparan sulfate proteoglycan biosynthetic process|
|myoblast fate commitment|
|negative regulation of type B pancreatic cell apoptotic process|
|maintenance of DNA repeat elements|
|regulation of type B pancreatic cell apoptotic process|
|armadillo repeat domain binding|
|gamma-catenin binding|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of protein export from nucleus|
|positive regulation of glycoprotein metabolic process|
|nuclear hormone receptor binding|
|beta-catenin-TCF complex assembly|
|RNA polymerase II repressing transcription factor binding|
|myoblast differentiation|
|Wnt signaling pathway, calcium modulating pathway|
|regulation of protein export from nucleus|
|regulation of hormone metabolic process|
|regulation of glycoprotein biosynthetic process|
|negative regulation of epithelial cell apoptotic process|
|protein-DNA complex|
|regulation of glycoprotein metabolic process|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of insulin secretion|
|pancreas development|
|regulation of epithelial cell apoptotic process|
|beta-catenin binding|
|regulation of epithelial to mesenchymal transition|
|canonical Wnt signaling pathway|
|positive regulation of protein binding|
|positive regulation of peptide hormone secretion|
|PML body|
|negative regulation of extrinsic apoptotic signaling pathway|
|fat cell differentiation|
|regulation of nucleocytoplasmic transport|
|positive regulation of hormone secretion|
|regulation of smooth muscle cell proliferation|
|non-canonical Wnt signaling pathway|
|response to glucose|
|response to hexose|
|cell cycle arrest|
|response to monosaccharide|
|positive regulation of intracellular protein transport|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of protein kinase B signaling|
|response to carbohydrate|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of binding|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of epithelial cell proliferation|
|transcription factor complex|
|positive regulation of intracellular transport|
|regulation of peptide hormone secretion|
|negative regulation of Wnt signaling pathway|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|regulation of intracellular protein transport|
|nuclear chromatin|
|cell fate commitment|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of canonical Wnt signaling pathway|
|positive regulation of peptide secretion|
|positive regulation of cellular protein localization|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|regulation of intracellular transport|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|regulation of binding|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|sequence-specific DNA binding|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|muscle structure development|
|blood vessel development|
|regulation of peptide secretion|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|regulation of hormone levels|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|DNA-binding transcription factor activity|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|chromosome organization|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.71|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.84|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.17|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.514|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCF7L2 Expression in NALM6 Cells: 3.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>