LILRB4

Gene Information

Official Symbol: LILRB4
Official Name: leukocyte immunoglobulin like receptor B4
Aliases and Previous Symbols: N/A
Entrez ID: 11006
UniProt: Q8NHJ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:9151699}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3775
Expression level (log2 read counts): 4.08

Expression Distribution

negative regulation of pri-miRNA transcription by RNA polymerase II
positive regulation of regulatory T cell differentiation
negative regulation of T cell receptor signaling pathway
negative regulation of antigen receptor-mediated signaling pathway
negative regulation of osteoclast differentiation
negative regulation of protein localization to nucleus
regulation of regulatory T cell differentiation
regulation of T cell receptor signaling pathway
regulation of pri-miRNA transcription by RNA polymerase II
negative regulation of myeloid leukocyte differentiation
regulation of antigen receptor-mediated signaling pathway
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
positive regulation of T cell differentiation
positive regulation of lymphocyte differentiation
negative regulation of leukocyte differentiation
negative regulation of cellular protein localization
regulation of myeloid leukocyte differentiation
regulation of protein localization to nucleus
negative regulation of hemopoiesis
regulation of T cell differentiation
antigen binding
positive regulation of leukocyte differentiation
regulation of lymphocyte differentiation
positive regulation of hemopoiesis
positive regulation of T cell activation
signaling receptor activity
positive regulation of leukocyte cell-cell adhesion
regulation of myeloid cell differentiation
positive regulation of cell-cell adhesion
regulation of leukocyte differentiation
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of cell adhesion
positive regulation of leukocyte activation
positive regulation of cell activation
negative regulation of immune system process
regulation of hemopoiesis