RABGGTA

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:7991565}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

Screen	Score
Fluvastatin 2.2μM R06 exp282	-2.86
Cerivastatin 0.15μM R05 exp226	-2.63

Rab-protein geranylgeranyltransferase complex
Rab geranylgeranyltransferase activity
protein geranylgeranylation
protein prenylation
prenylation
Rab GTPase binding
visual perception
sensory perception of light stimulus
post-translational protein modification
protein heterodimerization activity
zinc ion binding
sensory perception
nervous system process
regulation of apoptotic process
protein-containing complex assembly
regulation of programmed cell death
regulation of cell death
protein-containing complex subunit organization
system process