SOCS4

Gene Information

Official Symbol: SOCS4
Official Name: suppressor of cytokine signaling 4
Aliases and Previous Symbols: N/A
Entrez ID: 122809
UniProt: Q8WXH5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11471
Expression level (log2 read counts): 7.24

Expression Distribution

Screen	Score
THZ531 0.225μM R08 exp444	-1.8
BI-6727 0.001μM R01 exp42	1.98

SH2
SOCS box
SOCS

negative regulation of epidermal growth factor-activated receptor activity
regulation of epidermal growth factor-activated receptor activity
negative regulation of protein tyrosine kinase activity
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of signaling receptor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of epidermal growth factor receptor signaling pathway
regulation of protein tyrosine kinase activity
regulation of ERBB signaling pathway
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of signaling receptor activity
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
negative regulation of protein kinase activity
negative regulation of kinase activity
regulation of cellular protein catabolic process
regulation of peptidyl-tyrosine phosphorylation
negative regulation of transferase activity
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
negative regulation of protein phosphorylation
positive regulation of catabolic process
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of growth
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
negative regulation of catalytic activity