PCDH12

Entrez Summary: N/A
UniProt Summary: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cadherin
Cadherin 2

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
labyrinthine layer development
neuron recognition
glycogen metabolic process
glucan metabolic process
cellular glucan metabolic process
energy reserve metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
embryonic placenta development
placenta development
homophilic cell adhesion via plasma membrane adhesion molecules
cellular carbohydrate metabolic process
cell-cell junction
energy derivation by oxidation of organic compounds
cell recognition
cell-cell adhesion via plasma-membrane adhesion molecules
in utero embryonic development
generation of precursor metabolites and energy
reproductive structure development
reproductive system development
embryonic organ development
carbohydrate metabolic process
cell-cell adhesion
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
calcium ion binding
neuron development
cell adhesion
biological adhesion
oxidation-reduction process
embryo development
neuron differentiation
integral component of plasma membrane
reproductive process
reproduction
generation of neurons
neurogenesis
cell development