NANOS3

Gene Information

Official Symbol: N/ANOS3
Official Name: nanos C2HC-type zinc finger 3
Aliases and Previous Symbols: N/A
Entrez ID: 342977
UniProt: P60323
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5554
Expression level (log2 read counts): -3.59

Expression Distribution

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of mRNA catabolic process
cytoplasmic stress granule
oogenesis
positive regulation of mRNA metabolic process
P-body
female gamete generation
negative regulation of translation
negative regulation of cellular amide metabolic process
regulation of mRNA catabolic process
negative regulation of apoptotic signaling pathway
germ cell development
regulation of mRNA metabolic process
regulation of translation
cellular process involved in reproduction in multicellular organism
positive regulation of cellular catabolic process
regulation of apoptotic signaling pathway
regulation of cellular amide metabolic process
positive regulation of catabolic process
posttranscriptional regulation of gene expression
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
perinuclear region of cytoplasm
multicellular organismal reproductive process
sexual reproduction
regulation of cellular catabolic process
zinc ion binding
multicellular organism reproduction
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of catabolic process
negative regulation of cell death
multi-organism reproductive process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
regulation of cell cycle
negative regulation of signal transduction