MICALL2

Entrez Summary: N/A
UniProt Summary: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin filament bundle
actinin binding
filamin binding
actin filament polymerization
positive regulation of protein targeting to mitochondrion
bicellular tight junction assembly
tight junction assembly
endocytic recycling
tight junction organization
regulation of protein targeting to mitochondrion
apical junction assembly
actin polymerization or depolymerization
substrate adhesion-dependent cell spreading
positive regulation of establishment of protein localization to mitochondrion
actin cytoskeleton reorganization
stress fiber
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
protein polymerization
cell-cell junction assembly
positive regulation of mitochondrion organization
recycling endosome
bicellular tight junction
cell-cell junction organization
Rab GTPase binding
positive regulation of intracellular protein transport
cell junction assembly
cell-cell junction
regulation of mitochondrion organization
cell-substrate adhesion
actin filament binding
positive regulation of intracellular transport
cell junction organization
endosomal transport
regulation of intracellular protein transport
actin filament organization
neuron projection
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport