TRIM36

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ1 0.06μM R08 exp531	-2.12
UMK57 1μM R01 exp59	1.83
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.95
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.99
UM0011500 5μM R05 exp245	1.99
2-Methoxyestradiol 0.2μM R01 exp40	2
Rapamycin 1μM R00 exp29	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acrosome reaction
alpha-tubulin binding
mitotic cytokinesis
acrosomal vesicle
cytoskeleton-dependent cytokinesis
cytokinesis
single fertilization
spindle organization
fertilization
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
ubiquitin-protein transferase activity
protein polyubiquitination
cytoskeleton
microtubule cytoskeleton organization
cell division
regulation of cytoskeleton organization
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
protein ubiquitination
protein modification by small protein conjugation
sexual reproduction
zinc ion binding
protein modification by small protein conjugation or removal
multi-organism reproductive process
cell cycle process
cytoskeleton organization
regulation of cell cycle
regulation of organelle organization
cell cycle
reproductive process
reproduction