TRIM36 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM36
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 36
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55521|55521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ86|Q9NQ86]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|fn3|
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acrosome reaction|
|alpha-tubulin binding|
|mitotic cytokinesis|
|acrosomal vesicle|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|single fertilization|
|spindle organization|
|fertilization|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|cytoskeleton|
|microtubule cytoskeleton organization|
|cell division|
|regulation of cytoskeleton organization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|protein ubiquitination|
|protein modification by small protein conjugation|
|sexual reproduction|
|zinc ion binding|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.12|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.83|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.95|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.99|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.99|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.457|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13022
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM36 Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>