ATP5G2

Gene Information

Official Symbol: ATP5MC2
Official Name: ATP synthase membrane subunit c locus 2
Aliases and Previous Symbols: N/A
Entrez ID: 517
UniProt: Q06055
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11106
Expression level (log2 read counts): 7.39

Expression Distribution

proton-transporting ATP synthase complex, coupling factor F(o)
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
proton-transporting ATP synthase activity, rotational mechanism
mitochondrial ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP synthesis coupled proton transport
cristae formation
ATP biosynthetic process
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
nucleoside triphosphate metabolic process
oxidative phosphorylation
mitochondrial membrane organization
proton transmembrane transport
purine ribonucleotide biosynthetic process
lipid binding
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
mitochondrial outer membrane
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
ATP metabolic process
mitochondrial transport
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
monovalent inorganic cation transport
generation of precursor metabolites and energy
mitochondrion organization