COQ10A

Entrez Summary: N/A
UniProt Summary: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable). {ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquinone binding
ubiquinone biosynthetic process
quinone biosynthetic process
ubiquinone metabolic process
ketone biosynthetic process
quinone metabolic process
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
coenzyme biosynthetic process
cellular respiration
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
coenzyme metabolic process
mitochondrial inner membrane
generation of precursor metabolites and energy
cofactor metabolic process
small molecule biosynthetic process
oxidation-reduction process
mitochondrion
small molecule metabolic process