POU2F1

Gene Information

Official Symbol: POU2F1
Official Name: POU class 2 homeobox 1
Aliases and Previous Symbols: N/A
Entrez ID: 5451
UniProt: P14859
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-2.21
Rotenone 20μM R00 exp34	-1.93
Artemisinin 50μM R08 exp450	1.79
IWR1 50μM R08 exp495	1.79
Benzoate 10000μM R08 exp455	1.9
Rapamycin 10μM R00 exp30	1.93
GSK626616 14μM R08 exp485	1.96
Etoposide 0.1μM R05 exp198	1.98
Dimethyl-Sulfoxide 1pc R03 exp120	2.02
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.05
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.31
Calcium Ionophore 0.4μM R07 exp342	2.57
Cannabidiol 20μM R08 exp466	2.66
Thapsigargin 0.005μM R07 exp407	2.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13298
Expression level (log2 read counts): 6.96

Expression Distribution

Gene	Correlation
RBM26	0.417
RRM1	0.412
CTR9	0.402

Homeobox
Pou

RNA polymerase II core promoter sequence-specific DNA binding
snRNA transcription by RNA polymerase II
snRNA transcription
RNA polymerase II transcription factor complex
ncRNA transcription
sequence-specific DNA binding
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cytokine-mediated signaling pathway
intracellular membrane-bounded organelle
cellular response to cytokine stimulus
endoplasmic reticulum
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process