SORBS3

Entrez Summary: This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vinculin binding
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
structural constituent of cytoskeleton
cell-substrate adhesion
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
actin filament organization
muscle contraction
regulation of actin filament organization
muscle system process
transcription factor binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
regulation of actin filament-based process
focal adhesion
supramolecular fiber organization
actin cytoskeleton organization
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of MAPK cascade
actin filament-based process
positive regulation of organelle organization
regulation of MAPK cascade
negative regulation of transcription by RNA polymerase II
cell adhesion
biological adhesion
regulation of cellular component biogenesis
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
cytoskeleton organization
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization