DAAM2

Entrez Summary: N/A
UniProt Summary: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. {ECO:0000250|UniProtKB:Q80U19}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of oligodendrocyte differentiation
dorsal spinal cord development
regulation of non-canonical Wnt signaling pathway
negative regulation of glial cell differentiation
Rho GTPase binding
regulation of oligodendrocyte differentiation
negative regulation of gliogenesis
regulation of glial cell differentiation
spinal cord development
regulation of gliogenesis
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
actin binding
regulation of canonical Wnt signaling pathway
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
pattern specification process
actin cytoskeleton organization
actin filament-based process
negative regulation of cell differentiation
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
central nervous system development
cytoskeleton organization
cell-cell signaling
negative regulation of multicellular organismal process
generation of neurons
neurogenesis
positive regulation of signal transduction
regulation of cell differentiation