MICB

Gene Information

Official Symbol: MICB
Official Name: MHC class I polypeptide-related sequence B
Aliases and Previous Symbols: N/A
Entrez ID: 4277
UniProt: Q29980
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
UniProt Summary: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14543
Expression level (log2 read counts): 5.15

Expression Distribution

Screen	Score
HMS-I2 1μM R06 exp286	-1.89
Cyclosporin-A 0.8μM R07 exp347	1.71

MHC I
C1-set

negative regulation of defense response to virus by host
gamma-delta T cell activation
natural killer cell lectin-like receptor binding
susceptibility to natural killer cell mediated cytotoxicity
T cell mediated cytotoxicity
cytolysis
negative regulation of defense response to virus
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
regulation of defense response to virus by host
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of defense response to virus
regulation of leukocyte mediated cytotoxicity
cell killing
negative regulation of response to biotic stimulus
regulation of cell killing
positive regulation of lymphocyte mediated immunity
response to retinoic acid
response to heat
negative regulation of immune effector process
positive regulation of leukocyte mediated immunity
regulation of lymphocyte mediated immunity
response to temperature stimulus
regulation of leukocyte mediated immunity
negative regulation of defense response
negative regulation of multi-organism process
positive regulation of immune effector process
T cell activation
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of innate immune response
response to acid chemical