LY6H

Entrez Summary: N/A
UniProt Summary: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. {ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acetylcholine receptor inhibitor activity
acetylcholine receptor binding
acetylcholine receptor signaling pathway
cellular response to acetylcholine
response to acetylcholine
postsynaptic signal transduction
negative regulation of signaling receptor activity
signal transduction involved in cellular response to ammonium ion
anchored component of membrane
cellular response to ammonium ion
regulation of signaling receptor activity
response to ammonium ion
cellular response to drug
synaptic signaling
cellular response to hormone stimulus
cellular response to nitrogen compound
response to hormone
animal organ morphogenesis
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
negative regulation of molecular function
cellular response to endogenous stimulus
response to endogenous stimulus
response to oxygen-containing compound
extracellular region