KDM1B

Entrez Summary: N/A
UniProt Summary: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone demethylase activity (H3-monomethyl-K4 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
histone H3-K4 demethylation
regulation of gene expression by genetic imprinting
DNA methylation involved in gamete generation
genetic imprinting
regulation of DNA methylation
histone lysine demethylation
histone demethylation
protein demethylation
protein dealkylation
FAD binding
DNA alkylation
DNA methylation
demethylation
DNA methylation or demethylation
nucleosome
DNA modification
oxidoreductase activity
histone binding
regulation of gene expression, epigenetic
macromolecule methylation
protein deubiquitination
protein modification by small protein removal
methylation
regulation of DNA metabolic process
cellular process involved in reproduction in multicellular organism
histone modification
covalent chromatin modification
gamete generation
chromatin organization
DNA metabolic process
multicellular organismal reproductive process
sexual reproduction
zinc ion binding
multicellular organism reproduction
oxidation-reduction process
protein modification by small protein conjugation or removal
multi-organism reproductive process
chromosome organization