TRIM38

Gene Information

Official Symbol: TRIM38
Official Name: tripartite motif containing 38
Aliases and Previous Symbols: N/A
Entrez ID: 10475
UniProt: O00635
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. {ECO:0000269|PubMed:23056470}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17958
Expression level (log2 read counts): 7.1

Expression Distribution

Gene	Correlation
RRM1	0.536
PRIM1	0.411

SPRY
zf-C3HC4
zf-B box

positive regulation of viral entry into host cell
negative regulation of defense response to virus
regulation of viral entry into host cell
positive regulation of viral genome replication
regulation of interferon-beta production
protein K48-linked ubiquitination
transferase activity
positive regulation of viral life cycle
interferon-gamma-mediated signaling pathway
regulation of defense response to virus
negative regulation of response to biotic stimulus
regulation of viral genome replication
positive regulation of viral process
negative regulation of immune effector process
regulation of type I interferon production
regulation of viral life cycle
positive regulation of NF-kappaB transcription factor activity
cellular response to interferon-gamma
response to interferon-gamma
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of viral process
negative regulation of defense response
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA-binding transcription factor activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
negative regulation of response to external stimulus
regulation of DNA-binding transcription factor activity
negative regulation of immune system process
cellular component
regulation of immune effector process
positive regulation of multi-organism process
regulation of response to biotic stimulus
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process