RPS17L

Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
iCRT14 30μM R08 exp492	-3.28
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-3.26
UNC1999 2μM R03 exp155	-2.5
Nutlin-3A 1.6μM R06 exp294	-2.26
Rotenone 2μM R00 exp33	-2.1
Cyclosporin-A 0.8μM R07 exp347	-2.07
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.04
GSK343 3μM R03 exp124	-2.02
Mitomycin-C 0.06μM R08 exp503	-1.96
MS023 7μM R03 exp135	-1.9
Pyrazinamide 100μM R08 exp516	-1.79
BI-2536 0.02μM R03 exp96	-1.73
Genistein 15μM R07 exp360	-1.72
Lead acetate 2000μM R08 exp497	-1.72
RK-33 8μM R08 exp518	-1.7
GSK461364A 0.005μM R03 exp125	1.75
IU1-C 25μM R04 exp183	1.81
Nifuroxazide 1μM R01 exp51	2.04
BI-6727 0.0125μM R03 exp97	2.13
3-Bromopyruvate 7μM R04 exp175	2.14
BI-2536 0.001μM R01 exp41	2.31

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
RRM1	0.484
RPS27A	0.423

ribosome
cytosolic small ribosomal subunit
ribosomal small subunit biogenesis
erythrocyte homeostasis
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
myeloid cell homeostasis
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
viral transcription
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
viral gene expression
protein localization to endoplasmic reticulum
translational initiation
protein targeting to membrane
structural constituent of ribosome
nuclear-transcribed mRNA catabolic process
homeostasis of number of cells
rRNA processing
mRNA catabolic process
rRNA metabolic process
RNA catabolic process
establishment of protein localization to membrane
synapse
ribosome biogenesis
protein targeting
nucleobase-containing compound catabolic process
translation
ncRNA processing
peptide biosynthetic process
focal adhesion
establishment of protein localization to organelle
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
protein localization to membrane
organic cyclic compound catabolic process
amide biosynthetic process