STK25
Gene Information
- Official Symbol: STK25
- Official Name: serine/threonine kinase 25
- Aliases and Previous Symbols: N/A
- Entrez ID: 10494
- UniProt: O00506
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. {ECO:0000269|PubMed:15037601}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| hydrogen peroxide-mediated programmed cell death |
| programmed cell death in response to reactive oxygen species |
| intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| Golgi reassembly |
| cell death in response to hydrogen peroxide |
| establishment of Golgi localization |
| Golgi inheritance |
| organelle inheritance |
| Golgi localization |
| intrinsic apoptotic signaling pathway in response to oxidative stress |
| cell death in response to oxidative stress |
| cellular response to hydrogen peroxide |
| positive regulation of axonogenesis |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| cellular response to reactive oxygen species |
| Golgi organization |
| stress-activated protein kinase signaling cascade |
| intrinsic apoptotic signaling pathway |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of axonogenesis |
| protein autophosphorylation |
| response to reactive oxygen species |
| establishment or maintenance of cell polarity |
| cellular response to toxic substance |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| cellular response to oxidative stress |
| positive regulation of neuron projection development |
| apoptotic signaling pathway |
| regulation of cell morphogenesis involved in differentiation |
| response to antibiotic |
| activation of protein kinase activity |
| establishment of organelle localization |
| protein serine/threonine kinase activity |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| response to oxidative stress |
| signal transduction by protein phosphorylation |
| cellular response to drug |
| endomembrane system organization |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| response to toxic substance |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| organelle localization |
| Golgi membrane |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of kinase activity |
| protein homodimerization activity |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell death |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TIC10 10μM R08 exp532 | -2.24 |
| UM131593 0.1μM R01 exp58 | -1.71 |
| Rifampicin 30μM R08 exp430 | 1.79 |
| 42°C R08 exp539 | 1.88 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.637 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12544
- Expression level (log2 read counts): 6.55
Expression Distribution
STK25 Expression in NALM6 Cells: 6.55
