MAP3K6

Gene Information

Official Symbol: MAP3K6
Official Name: mitogen-activated protein kinase kinase kinase 6
Aliases and Previous Symbols: N/A
Entrez ID: 9064
UniProt: O95382
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6788
Expression level (log2 read counts): 3.48

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.79
ABT-702 5μM R07 exp318	-1.73
Nifuroxazide 1μM R01 exp51	-1.7
Sulforaphane 9μM R08 exp525	1.86

Pkinase Tyr
Pkinase

MAP kinase kinase kinase activity
activation of JUN kinase activity
activation of MAPKK activity
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
stress-activated MAPK cascade
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
magnesium ion binding
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein kinase activity
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of cellular response to stress
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process