MAP4K4
Gene Information
- Official Symbol: MAP4K4
- Official Name: mitogen-activated protein kinase kinase kinase kinase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 9448
- UniProt: O95819
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
| CNH |
GO Terms
| positive regulation of ARF protein signal transduction |
| creatine kinase activity |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| positive regulation of keratinocyte migration |
| regulation of keratinocyte migration |
| negative regulation of neuron projection regeneration |
| microvillus assembly |
| microvillus organization |
| regulation of ARF protein signal transduction |
| positive regulation of focal adhesion assembly |
| regulation of neuron projection regeneration |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| negative regulation of cell-matrix adhesion |
| negative regulation of insulin secretion |
| negative regulation of peptide hormone secretion |
| positive regulation of cell-matrix adhesion |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| negative regulation of cell-substrate adhesion |
| negative regulation of hormone secretion |
| positive regulation of Ras protein signal transduction |
| regulation of adherens junction organization |
| positive regulation of small GTPase mediated signal transduction |
| regulation of cell junction assembly |
| regulation of cell-matrix adhesion |
| positive regulation of cell-substrate adhesion |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| positive regulation of epithelial cell migration |
| stress-activated protein kinase signaling cascade |
| negative regulation of neuron projection development |
| regulation of insulin secretion |
| negative regulation of cell projection organization |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of JNK cascade |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| regulation of cell-substrate adhesion |
| regulation of epithelial cell migration |
| negative regulation of neuron differentiation |
| negative regulation of secretion |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| microtubule binding |
| regulation of Ras protein signal transduction |
| regulation of hormone secretion |
| negative regulation of cell adhesion |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| activation of protein kinase activity |
| negative regulation of cell development |
| regulation of small GTPase mediated signal transduction |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| focal adhesion |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| regulation of protein secretion |
| neuron projection morphogenesis |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| cell projection morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cell part morphogenesis |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| positive regulation of kinase activity |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotine 3000μM R08 exp510 | 1.7 |
| Metformin 40μM R03 exp132 | 1.85 |
| LB-100 2μM R05 exp210 | 2.3 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.542 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6147
- Expression level (log2 read counts): 8.11
Expression Distribution
MAP4K4 Expression in NALM6 Cells: 8.11
