MAP4K4 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP4K4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP4K4
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase kinase kinase kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9448|9448]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95819|O95819]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP4K4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP4K4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604666|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|CNH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ARF protein signal transduction|
|creatine kinase activity|
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of keratinocyte migration|
|regulation of keratinocyte migration|
|negative regulation of neuron projection regeneration|
|microvillus assembly|
|microvillus organization|
|regulation of ARF protein signal transduction|
|positive regulation of focal adhesion assembly|
|regulation of neuron projection regeneration|
|positive regulation of adherens junction organization|
|positive regulation of cell junction assembly|
|negative regulation of cell-matrix adhesion|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|positive regulation of cell-matrix adhesion|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|negative regulation of hormone secretion|
|positive regulation of Ras protein signal transduction|
|regulation of adherens junction organization|
|positive regulation of small GTPase mediated signal transduction|
|regulation of cell junction assembly|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|positive regulation of epithelial cell migration|
|stress-activated protein kinase signaling cascade|
|negative regulation of neuron projection development|
|regulation of insulin secretion|
|negative regulation of cell projection organization|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of JNK cascade|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|negative regulation of neuron differentiation|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|microtubule binding|
|regulation of Ras protein signal transduction|
|regulation of hormone secretion|
|negative regulation of cell adhesion|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|activation of protein kinase activity|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of protein secretion|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.7|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.85|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.542|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP4K4 Expression in NALM6 Cells: 8.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>