TESK1

Gene Information

Official Symbol: TESK1
Official Name: testis associated actin remodelling kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 7016
UniProt: Q15569
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9862
Expression level (log2 read counts): 4.56

Expression Distribution

Pkinase
Pkinase Tyr

negative regulation of protein autophosphorylation
protein serine/threonine/tyrosine kinase activity
regulation of protein autophosphorylation
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
regulation of stress fiber assembly
protein tyrosine kinase activity
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
negative regulation of protein serine/threonine kinase activity
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
protein C-terminus binding
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
negative regulation of protein kinase activity
negative regulation of kinase activity
cytoplasmic vesicle
regulation of actin filament organization
negative regulation of transferase activity
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
protein serine/threonine kinase activity
regulation of actin filament-based process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
actin cytoskeleton organization
regulation of protein serine/threonine kinase activity
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
spermatogenesis
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
male gamete generation
actin filament-based process
negative regulation of protein modification process
positive regulation of organelle organization
gamete generation
negative regulation of catalytic activity