GBP7

Entrez Summary: N/A
UniProt Summary: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GBP
GBP C

symbiont-containing vacuole membrane
defense response to protozoan
response to protozoan
defense response to Gram-positive bacterium
cellular response to interferon-gamma
response to interferon-gamma
cytoplasmic vesicle
defense response to bacterium
GTPase activity
GTP binding
response to bacterium
innate immune response
defense response to other organism
cellular response to cytokine stimulus
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
immune response
membrane