MCM7

Entrez Summary: N/A
UniProt Summary: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:9305914}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Atovaquone 15μM R08 exp451	-2.4
Etoposide 0.3μM R05 exp199	-2.16
Nutlin-3A 1.6μM R06 exp294	-1.99
Doxorubicin 0.02μM R08 exp478	-1.94
Milciclib 2μM R08 exp502	-1.91
Vinblastine 0.015μM R05 exp208	-1.81
Rotenone 0.07μM R08 exp431	-1.71
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.7
Campthothecin 0.001μM R06 exp270	1.87
MKC9989 10μM R03 exp133	1.93
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.04
BRD2 inhibitor II 20μM R07 exp341	2.12
Sulforaphane 9μM R08 exp525	2.25
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.55

Global Fraction of Cell Lines Where Essential: 727/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	32/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	73/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

single-stranded 3-5 DNA helicase activity
pre-replicative complex assembly involved in cell cycle DNA replication
pre-replicative complex assembly
pre-replicative complex assembly involved in nuclear cell cycle DNA replication
double-strand break repair via break-induced replication
MCM complex
DNA unwinding involved in DNA replication
DNA strand elongation involved in DNA replication
DNA strand elongation
DNA replication origin binding
DNA replication initiation
cellular response to epidermal growth factor stimulus
nuclear DNA replication
cell cycle DNA replication
response to epidermal growth factor
DNA helicase activity
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
nuclear chromosome, telomeric region
DNA duplex unwinding
chromatin
DNA geometric change
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
DNA-dependent DNA replication
double-strand break repair
cellular response to xenobiotic stimulus
protein-DNA complex assembly
DNA replication
DNA recombination
protein-DNA complex subunit organization
mitotic cell cycle phase transition
cell cycle phase transition
DNA conformation change
response to xenobiotic stimulus
cellular response to growth factor stimulus
DNA repair
response to growth factor
cell population proliferation