MCM7 [The Human Chemical-Genetic Interaction Map Project]

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======= MCM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCM7
  * **<color #00a2e8>Official Name</color>**: minichromosome maintenance complex component 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4176|4176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33993|P33993]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600592|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:9305914}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MCM|
|Mg chelatase|
|AAA 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|single-stranded 3-5 DNA helicase activity|
|pre-replicative complex assembly involved in cell cycle DNA replication|
|pre-replicative complex assembly|
|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|
|double-strand break repair via break-induced replication|
|MCM complex|
|DNA unwinding involved in DNA replication|
|DNA strand elongation involved in DNA replication|
|DNA strand elongation|
|DNA replication origin binding|
|DNA replication initiation|
|cellular response to epidermal growth factor stimulus|
|nuclear DNA replication|
|cell cycle DNA replication|
|response to epidermal growth factor|
|DNA helicase activity|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|DNA duplex unwinding|
|chromatin|
|DNA geometric change|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|double-strand break repair|
|cellular response to xenobiotic stimulus|
|protein-DNA complex assembly|
|DNA replication|
|DNA recombination|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|DNA conformation change|
|response to xenobiotic stimulus|
|cellular response to growth factor stimulus|
|DNA repair|
|response to growth factor|
|cell population proliferation|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|response to drug|
|chromosome organization|
|cellular response to endogenous stimulus|
|cell cycle|
|DNA binding|
|response to endogenous stimulus|
|ATP binding|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.4|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.16|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.99|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.94|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.91|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.81|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.71|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.7|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.87|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.93|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.04|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.12|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.25|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps2|RPS2]]|0.454|
|[[:human genes:g:golga8o|GOLGA8O]]|0.441|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.412|
|[[:human genes:c:ccna2|CCNA2]]|0.411|
|[[:human genes:r:rrm1|RRM1]]|0.407|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.404|
|[[:human genes:r:rpl6|RPL6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 727/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 579
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCM7 Expression in NALM6 Cells: 9.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>