RHOBTB2

Entrez Summary: The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

engulfment of apoptotic cell
apoptotic cell clearance
actin cytoskeleton reorganization
Rho protein signal transduction
positive regulation of actin filament polymerization
cell projection
positive regulation of protein polymerization
phagocytosis, engulfment
plasma membrane invagination
membrane invagination
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
small GTPase mediated signal transduction
phagocytosis
GTPase activity
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
cytoskeleton
regulation of cellular component size
regulation of actin filament-based process
GTP binding
regulation of protein complex assembly
supramolecular fiber organization
protein kinase binding
actin cytoskeleton organization
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
endocytosis
actin filament-based process
positive regulation of organelle organization