MYO1G

Entrez Summary: N/A
UniProt Summary: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Myosin head
Myosin TH1

T cell meandering migration
cell gliding
leading edge membrane
T cell migration
phagocytic cup
phosphatidylinositol-3,4-bisphosphate binding
myosin complex
phosphatidylinositol-3,4,5-trisphosphate binding
T cell mediated immunity
motor activity
microvillus
lymphocyte migration
filopodium
phosphatidylinositol-4,5-bisphosphate binding
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
lamellipodium
cell-substrate adhesion
calmodulin binding
Fc receptor signaling pathway
lymphocyte mediated immunity
actin binding
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
phagocytosis
leukocyte migration
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
immune response-activating signal transduction
immune response-regulating signaling pathway
adaptive immune response
activation of immune response
leukocyte mediated immunity
exocytosis
positive regulation of immune response
cell adhesion
biological adhesion
cell migration
secretion by cell