MYO1G [The Human Chemical-Genetic Interaction Map Project]

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======= MYO1G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1G
  * **<color #00a2e8>Official Name</color>**: myosin IG
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64005|64005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/B0I1T2|B0I1T2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin head|
|Myosin TH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T cell meandering migration|
|cell gliding|
|leading edge membrane|
|T cell migration|
|phagocytic cup|
|phosphatidylinositol-3,4-bisphosphate binding|
|myosin complex|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|T cell mediated immunity|
|motor activity|
|microvillus|
|lymphocyte migration|
|filopodium|
|phosphatidylinositol-4,5-bisphosphate binding|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|lamellipodium|
|cell-substrate adhesion|
|calmodulin binding|
|Fc receptor signaling pathway|
|lymphocyte mediated immunity|
|actin binding|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|phagocytosis|
|leukocyte migration|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|adaptive immune response|
|activation of immune response|
|leukocyte mediated immunity|
|exocytosis|
|positive regulation of immune response|
|cell adhesion|
|biological adhesion|
|cell migration|
|secretion by cell|
|export from cell|
|localization of cell|
|cell motility|
|immune effector process|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|locomotion|
|ATP binding|
|movement of cell or subcellular component|
|regulation of immune system process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.71|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.73|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.83|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2918
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1G Expression in NALM6 Cells: 2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>