HSPB11

Entrez Summary: N/A
UniProt Summary: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.015μM R05 exp208	-1.8
Golgicide-A 2μM R03 exp121	1.99

left/right axis specification
left/right pattern formation
intraciliary transport particle B
intraciliary transport involved in cilium assembly
ciliary tip
intraciliary transport
microtubule-based protein transport
protein transport along microtubule
smoothened signaling pathway
axis specification
transport along microtubule
lung development
respiratory tube development
cytoskeleton-dependent intracellular transport
microtubule-based transport
respiratory system development
cilium
protein-containing complex localization
kidney development
microtubule-based movement
renal system development
urogenital system development
regionalization
cilium assembly
cilium organization
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
skeletal system development
heart development
spermatogenesis
male gamete generation
microtubule-based process
gamete generation
organelle assembly
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
tube development