BNIP3L

Gene Information

Official Symbol: BNIP3L
Official Name: BCL2 interacting protein 3 like
Aliases and Previous Symbols: N/A
Entrez ID: 665
UniProt: O60238
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18527
Expression level (log2 read counts): 4.93

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.71

mitochondrial protein catabolic process
intrinsic component of membrane
negative regulation of mitochondrial membrane potential
negative regulation of membrane potential
mitochondrial outer membrane permeabilization
lamin binding
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
positive regulation of mitochondrial membrane permeability
positive regulation of membrane permeability
regulation of mitochondrial membrane permeability involved in apoptotic process
regulation of autophagy of mitochondrion
regulation of protein targeting to mitochondrion
apoptotic mitochondrial changes
positive regulation of macroautophagy
regulation of mitochondrial membrane potential
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
regulation of protein targeting
positive regulation of autophagy
mitochondrial membrane organization
mitochondrial outer membrane
regulation of macroautophagy
nuclear envelope
regulation of mitochondrion organization
cellular response to hypoxia
defense response to virus
cellular response to decreased oxygen levels
mitochondrial transport
cellular response to oxygen levels
regulation of intracellular protein transport
response to virus
apoptotic signaling pathway
regulation of autophagy
response to hypoxia
regulation of intracellular transport
response to decreased oxygen levels
positive regulation of cellular catabolic process
response to oxygen levels