BNIP3L [The Human Chemical-Genetic Interaction Map Project]

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======= BNIP3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BNIP3L
  * **<color #00a2e8>Official Name</color>**: BCL2 interacting protein 3 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=665|665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60238|O60238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BNIP3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BNIP3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605368|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BNIP3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial protein catabolic process|
|intrinsic component of membrane|
|negative regulation of mitochondrial membrane potential|
|negative regulation of membrane potential|
|mitochondrial outer membrane permeabilization|
|lamin binding|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of mitochondrial membrane permeability|
|positive regulation of membrane permeability|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|apoptotic mitochondrial changes|
|positive regulation of macroautophagy|
|regulation of mitochondrial membrane potential|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|regulation of protein targeting|
|positive regulation of autophagy|
|mitochondrial membrane organization|
|mitochondrial outer membrane|
|regulation of macroautophagy|
|nuclear envelope|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|defense response to virus|
|cellular response to decreased oxygen levels|
|mitochondrial transport|
|cellular response to oxygen levels|
|regulation of intracellular protein transport|
|response to virus|
|apoptotic signaling pathway|
|regulation of autophagy|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|nuclear speck|
|regulation of membrane potential|
|positive regulation of catabolic process|
|mitochondrion organization|
|protein heterodimerization activity|
|regulation of cellular protein localization|
|cellular protein catabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein catabolic process|
|positive regulation of cell death|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|apoptotic process|
|defense response to other organism|
|negative regulation of cell death|
|regulation of catabolic process|
|endoplasmic reticulum|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|immune effector process|
|response to abiotic stimulus|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.71|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.602|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BNIP3L Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>