TMEM55B

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. {ECO:0000269|PubMed:16365287}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
proton-transporting V-type ATPase complex assembly
response to sterol depletion
proton-transporting two-sector ATPase complex assembly
positive regulation of TORC1 signaling
phosphatidylinositol dephosphorylation
phospholipid dephosphorylation
regulation of TORC1 signaling
positive regulation of TOR signaling
lysosome localization
phagocytic vesicle membrane
regulation of TOR signaling
cholesterol metabolic process
late endosome membrane
secondary alcohol metabolic process
sterol metabolic process
phosphatidylinositol metabolic process
lipid modification
steroid metabolic process
lysosomal membrane
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organic hydroxy compound metabolic process
organelle localization
cellular protein-containing complex assembly
organophosphate metabolic process
cellular lipid metabolic process
positive regulation of intracellular signal transduction
lipid metabolic process
protein-containing complex assembly
positive regulation of signal transduction
small molecule metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
protein-containing complex subunit organization