SERINC3

Gene Information

Official Symbol: SERINC3
Official Name: serine incorporator 3
Aliases and Previous Symbols: N/A
Entrez ID: 10955
UniProt: Q13530
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.02
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.88
Mitomycin-C 0.06μM R08 exp503	-1.75
L-BMAA 500 to 750μM on day4 R04 exp185	-1.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13375
Expression level (log2 read counts): 6.73

Expression Distribution

detection of virus
L-serine biosynthetic process
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
L-serine metabolic process
serine family amino acid biosynthetic process
phosphatidylserine metabolic process
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of response to endoplasmic reticulum stress
serine family amino acid metabolic process
positive regulation of intrinsic apoptotic signaling pathway
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
regulation of response to endoplasmic reticulum stress
sphingolipid metabolic process
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
defense response to virus
cellular modified amino acid metabolic process
membrane lipid metabolic process
alpha-amino acid metabolic process
response to virus
carboxylic acid biosynthetic process
organic acid biosynthetic process
glycerophospholipid metabolic process
cellular amino acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
regulation of apoptotic signaling pathway
small molecule biosynthetic process
Golgi membrane
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
perinuclear region of cytoplasm
regulation of cellular response to stress
innate immune response
organophosphate metabolic process
carboxylic acid metabolic process
defense response to other organism
cellular lipid metabolic process