SERINC3 [The Human Chemical-Genetic Interaction Map Project]

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======= SERINC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERINC3
  * **<color #00a2e8>Official Name</color>**: serine incorporator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10955|10955]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13530|Q13530]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERINC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERINC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serinc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of virus|
|L-serine biosynthetic process|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|L-serine metabolic process|
|serine family amino acid biosynthetic process|
|phosphatidylserine metabolic process|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|serine family amino acid metabolic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|regulation of response to endoplasmic reticulum stress|
|sphingolipid metabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|defense response to virus|
|cellular modified amino acid metabolic process|
|membrane lipid metabolic process|
|alpha-amino acid metabolic process|
|response to virus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|cellular amino acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of apoptotic signaling pathway|
|small molecule biosynthetic process|
|Golgi membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|innate immune response|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|defense response to other organism|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|immune effector process|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.02|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.88|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.653|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERINC3 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>