FOXD4

Entrez Summary: This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 695/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	26/26
breast	28/33
central nervous system	53/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	20/20
lung	71/75
lymphocyte	16/16
ovary	25/26
pancreas	21/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	20/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	27/29
uterus	4/5

Expression Distribution

DNA binding, bending
sequence-specific DNA binding
DNA-binding transcription factor activity
DNA-binding transcription factor activity, RNA polymerase II-specific