FMNL1

Entrez Summary: N/A
UniProt Summary: May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin filament severing
bleb
profilin binding
GTPase activating protein binding
substrate-dependent cell migration
cortical actin cytoskeleton organization
cortical cytoskeleton organization
Rac GTPase binding
phagocytic vesicle
cell cortex
regulation of cell shape
actin filament binding
regulation of cell morphogenesis
actin cytoskeleton organization
actin filament-based process
molecular function
cell migration
regulation of anatomical structure morphogenesis
cell motility
localization of cell
cytoskeleton organization
locomotion
movement of cell or subcellular component
membrane