HS6ST1

Entrez Summary: The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:21700882}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heparan sulfate 6-O-sulfotransferase activity
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
labyrinthine layer blood vessel development
heparan sulfate proteoglycan biosynthetic process
placenta blood vessel development
sulfotransferase activity
heparan sulfate proteoglycan metabolic process
lung alveolus development
labyrinthine layer development
proteoglycan biosynthetic process
embryonic placenta development
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
placenta development
glycosaminoglycan metabolic process
aminoglycan metabolic process
lung development
respiratory tube development
respiratory system development
angiogenesis
glycoprotein biosynthetic process
in utero embryonic development
glycoprotein metabolic process
blood vessel morphogenesis
reproductive structure development
reproductive system development
embryonic organ development
blood vessel development
vasculature development
cardiovascular system development
carbohydrate derivative biosynthetic process
Golgi membrane
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
developmental process involved in reproduction
neuron development
tube development
circulatory system development