HS6ST1 [The Human Chemical-Genetic Interaction Map Project]

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======= HS6ST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HS6ST1
  * **<color #00a2e8>Official Name</color>**: heparan sulfate 6-O-sulfotransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9394|9394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60243|O60243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HS6ST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HS6ST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269|PubMed:21700882}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heparan sulfate 6-O-sulfotransferase activity|
|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|
|labyrinthine layer blood vessel development|
|heparan sulfate proteoglycan biosynthetic process|
|placenta blood vessel development|
|sulfotransferase activity|
|heparan sulfate proteoglycan metabolic process|
|lung alveolus development|
|labyrinthine layer development|
|proteoglycan biosynthetic process|
|embryonic placenta development|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|aminoglycan biosynthetic process|
|placenta development|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|lung development|
|respiratory tube development|
|respiratory system development|
|angiogenesis|
|glycoprotein biosynthetic process|
|in utero embryonic development|
|glycoprotein metabolic process|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|neuron development|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|cell development|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.715|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HS6ST1 Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>