TNK1

Entrez Summary: N/A
UniProt Summary: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

peptidyl-tyrosine autophosphorylation
non-membrane spanning protein tyrosine kinase activity
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
protein tyrosine kinase activity
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
negative regulation of cell growth
protein autophosphorylation
negative regulation of growth
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
regulation of cell growth
negative regulation of intracellular signal transduction
regulation of growth
peptidyl-amino acid modification
protein phosphorylation
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ATP binding
regulation of cell population proliferation
negative regulation of response to stimulus
regulation of intracellular signal transduction
membrane