IL5RA
Gene Information
- Official Symbol: IL5RA
- Official Name: interleukin 5 receptor subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 3568
- UniProt: Q01344
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].
- UniProt Summary: This is the receptor for interleukin-5. The alpha chain binds to IL5.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18243
- Expression level (log2 read counts): 0.94
IL5RA Expression in NALM6 Cells: 0.94
