PIK3AP1

Gene Information

Official Symbol: PIK3AP1
Official Name: phosphoinositide-3-kinase adaptor protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 118788
UniProt: Q6ZUJ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12360
Expression level (log2 read counts): 8.95

Expression Distribution

Screen	Score
Quercetin 20μM R08 exp517	-2.27
Q15 2.7μM R02 exp79	-2.2
THZ1 0.06μM R08 exp531	-1.73
Rapamycin 2μM R07 exp306	2.26

toll-like receptor 7 signaling pathway
toll-like receptor 2 signaling pathway
phosphatidylinositol 3-kinase regulatory subunit binding
toll-like receptor 9 signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
toll-like receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
pattern recognition receptor signaling pathway
positive regulation of protein kinase B signaling
regulation of protein kinase B signaling
innate immune response-activating signal transduction
activation of innate immune response
signaling receptor binding
regulation of inflammatory response
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
positive regulation of intracellular signal transduction
identical protein binding
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
regulation of response to stress
positive regulation of signal transduction
regulation of immune system process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
membrane