BRINP3

Entrez Summary: N/A
UniProt Summary: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. {ECO:0000269|PubMed:17138656}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	-2.23
Pomalidomide 20μM R07 exp391	1.87

cellular response to retinoic acid
response to retinoic acid
cell cycle arrest
cellular response to acid chemical
negative regulation of mitotic cell cycle
response to acid chemical
positive regulation of neuron differentiation
neuronal cell body
dendrite
positive regulation of neurogenesis
cellular response to lipid
positive regulation of nervous system development
positive regulation of cell development
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of neuron differentiation
regulation of neurogenesis
response to lipid
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
cell cycle process
endoplasmic reticulum
cellular response to oxygen-containing compound
regulation of cell cycle
mitochondrion
cell cycle
positive regulation of developmental process
generation of neurons
response to oxygen-containing compound
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation
extracellular region