FAM179B

Entrez Summary: N/A
UniProt Summary: Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). {ECO:0000250|UniProtKB:Q17423, ECO:0000250|UniProtKB:Q6A070}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of microtubule polymerization
positive regulation of microtubule polymerization or depolymerization
non-motile cilium assembly
regulation of microtubule polymerization
axoneme assembly
regulation of microtubule polymerization or depolymerization
microtubule bundle formation
positive regulation of protein polymerization
ciliary basal body
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
cilium
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
positive regulation of protein complex assembly
microtubule
cilium assembly
regulation of supramolecular fiber organization
cilium organization
plasma membrane bounded cell projection assembly
regulation of protein complex assembly
cell projection assembly
microtubule cytoskeleton organization
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of organelle organization
microtubule-based process
organelle assembly
regulation of cellular component biogenesis
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of cellular component organization
regulation of organelle organization