RAB20

Entrez Summary: N/A
UniProt Summary: Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269|PubMed:21255211}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phagosome-lysosome fusion
phagolysosome assembly
phagosome acidification
phagosome maturation
intracellular pH reduction
pH reduction
endocytic vesicle
lysosome organization
lytic vacuole organization
phagocytic vesicle
vesicle fusion
Rab protein signal transduction
phagocytic vesicle membrane
organelle membrane fusion
regulation of intracellular pH
regulation of cellular pH
organelle fusion
regulation of pH
cellular monovalent inorganic cation homeostasis
vacuole organization
membrane fusion
monovalent inorganic cation homeostasis
cellular response to interferon-gamma
response to interferon-gamma
regulation of endocytosis
Ras protein signal transduction
early endosome
endosome
vesicle organization
small GTPase mediated signal transduction
phagocytosis
GTPase activity
GTP binding
regulation of vesicle-mediated transport
endocytosis
cellular cation homeostasis
cellular ion homeostasis
import into cell
intracellular membrane-bounded organelle
cation homeostasis