RAB20 [The Human Chemical-Genetic Interaction Map Project]

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======= RAB20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB20
  * **<color #00a2e8>Official Name</color>**: RAB20, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55647|55647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX57|Q9NX57]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. {ECO:0000269|PubMed:21255211}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagosome-lysosome fusion|
|phagolysosome assembly|
|phagosome acidification|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|endocytic vesicle|
|lysosome organization|
|lytic vacuole organization|
|phagocytic vesicle|
|vesicle fusion|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|organelle membrane fusion|
|regulation of intracellular pH|
|regulation of cellular pH|
|organelle fusion|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|vacuole organization|
|membrane fusion|
|monovalent inorganic cation homeostasis|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|regulation of endocytosis|
|Ras protein signal transduction|
|early endosome|
|endosome|
|vesicle organization|
|small GTPase mediated signal transduction|
|phagocytosis|
|GTPase activity|
|GTP binding|
|regulation of vesicle-mediated transport|
|endocytosis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|import into cell|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|organelle assembly|
|innate immune response|
|ion homeostasis|
|membrane organization|
|cellular homeostasis|
|defense response to other organism|
|Golgi apparatus|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|chemical homeostasis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12622
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB20 Expression in NALM6 Cells: 3.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>