KDM4E

Entrez Summary: The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016].
UniProt Summary: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. {ECO:0000269|PubMed:21914792}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

JmjC
JmjN

histone demethylase activity (H3-K9 specific)
histone H3-K9 demethylation
histone demethylase activity
dioxygenase activity
histone lysine demethylation
histone demethylation
protein dealkylation
protein demethylation
histone methyltransferase complex
demethylation
chromatin remodeling
histone modification
covalent chromatin modification
chromatin organization
oxidation-reduction process
chromosome organization