AES

Gene Information

Official Symbol: TLE5
Official Name: TLE family member 5, transcriptional modulator
Aliases and Previous Symbols: N/A
Entrez ID: 166
UniProt: Q08117
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13239
Expression level (log2 read counts): 7.17

Expression Distribution

Screen	Score
Hydroxychloroquine 30μM R08 exp490	-1.92
TIC10 10μM R08 exp532	1.72
PU-H71 1μM R08 exp515	1.78

positive regulation of anoikis
regulation of anoikis
repressing transcription factor binding
negative regulation of response to cytokine stimulus
negative regulation of protein binding
negative regulation of binding
negative regulation of canonical Wnt signaling pathway
regulation of response to cytokine stimulus
response to interleukin-1
transcription factor complex
negative regulation of Wnt signaling pathway
regulation of protein binding
transcription corepressor activity
cellular response to extracellular stimulus
regulation of canonical Wnt signaling pathway
cellular response to external stimulus
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
regulation of binding
cell surface receptor signaling pathway involved in cell-cell signaling
skeletal system development
response to extracellular stimulus
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
positive regulation of cell death
negative regulation of transcription by RNA polymerase II
animal organ morphogenesis
response to cytokine
cell-cell signaling
negative regulation of molecular function
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process