LPPR4

Entrez Summary: N/A
UniProt Summary: Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. {ECO:0000269|PubMed:12730698}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipid phosphatase activity
phosphatidate phosphatase activity
phospholipid dephosphorylation
phosphatase activity
integral component of postsynaptic density membrane
inner ear development
lipid modification
ear development
dephosphorylation
glutamatergic synapse
axonogenesis
phospholipid metabolic process
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
sensory organ development
cell morphogenesis involved in differentiation
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
organophosphate metabolic process
cellular lipid metabolic process
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
lipid metabolic process
integral component of plasma membrane
generation of neurons
neurogenesis
cell development